In a pioneering effort at London's Great Ormond Street Hospital, a novel form of drug treatment, considerably less toxic than conventional chemotherapy, is bringing hope to children battling cancer. Among the first recipients is 11-year-old Arthur, who, having exhausted traditional chemotherapy options, found success with the therapy known as blinatumomab, or "blina." Arthur's family aptly refers to this treatment as "a little bit of sunshine" since it proved effective without causing significant distress.
Unlike conventional chemotherapy, blina operates as an immunotherapy, specifically targeting cancer cells while preserving healthy ones. Administered through a thin plastic tube, the treatment involves a bag of liquid connected to a battery-operated pump, allowing for extended use over many months. This portable system, contained within a backpack, enables patients like Arthur to undergo treatment outside the hospital setting, affording them a more flexible and comfortable experience.
Blina has already received approval for treating cancer in adults, and ongoing efforts aim to establish its safety and efficacy for pediatric patients. Approximately 20 centers across the UK are utilizing blina off-label to address B-cell acute lymphoblastic leukaemia (B-ALL) in children.
Professor Ajay Vora, Chief Investigator and consultant pediatric haematologist, underscores the revolutionary nature of blina, describing it as a "gentler, kinder treatment" in comparison to traditional chemotherapies. With the potential to replace a significant portion of chemotherapy, blina offers a more targeted and less toxic approach to pediatric cancer treatment.
This breakthrough comes as a ray of hope for the roughly 450 children diagnosed annually in the UK with B-ALL, providing a promising alternative to conventional, harsher treatments. For Arthur and his family, the success of blina has marked a new beginning, with his cancer now eradicated, bringing joyous celebrations and renewed optimism for the future.
Source: Roberts, Michelle. BBC. "Exciting new cancer drug kinder than chemotherapy". https://www.bbc.com/news/health-67793887. 17/01/2024. [Date accessed: 20/01/2024].
Edited by: Manan Chordia
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