Researchers at KAIST, led by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering, have developed a revolutionary approach to cancer treatment by converting cancer cells into normal-like cells, eliminating the need to destroy them. Unlike traditional therapies that aim to kill cancer cells but often lead to resistance and harmful side effects, this method focuses on reprogramming cancer cells into a healthy state.
The team created a "digital twin" of the gene network that governs cell differentiation. Using advanced simulation analysis, they identified molecular switches that control the differentiation process. When these switches were applied to colon cancer cells, the cells reverted to a state resembling normal colon cells. This breakthrough was validated through molecular experiments, cellular studies, and animal models.
Professor Cho highlighted the potential of this approach, describing it as a "reversible cancer therapy" that systematically induces cancer cell reversion. The findings could be applied to various cancer types, offering a paradigm shift in treatment.
The study, published in Advanced Science on December 11, represents a foundational advancement in identifying targets for cancer reversion. This groundbreaking work promises safer, side-effect-free cancer therapies and redefines how cancer can be treated.
The research team’s findings are detailed in the article “Control of Cellular Differentiation Trajectories for Cancer Reversion.” DOI: https://doi.org/10.1002/advs.202402132.
Source. Advanced Science. "Control of Cellular Differentiation Trajectories for Cancer Reversion" DOI: https://doi.org/10.1002/advs.202402132. 11 Dec 2024.
Edited by Ansh Pincha.
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